{"title":"Daily Essentials","description":"Iron, D3 with K2, and appetite balance. The best-evidenced products in the catalog sit in here, and so does the weakest. Both are labelled.","products":[{"product_id":"balance-appetite","title":"RUNTIME Balance","description":"\u003cp class=\"rb-lede\"\u003eChromium, saffron and molybdenum. This is the weakest evidence-to-dose ratio in the catalog and the page is going to tell you exactly why.\u003c\/p\u003e\n\u003cp class=\"rb-note\"\u003eThe chromium trial at 500–1,000 mcg found no benefit in the population most likely to show one. This strip carries 75 mcg. Read the rows before ordering.\u003c\/p\u003e\n\u003ch3\u003eSpec\u003c\/h3\u003e\n\u003ctable class=\"rb-spec\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eChromium (Chromium Picolinate)\u003c\/th\u003e\n\u003ctd\u003e75 mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSaffron (Crocus sativus)\u003c\/th\u003e\n\u003ctd\u003e10 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolybdenum (Molybdenum Glycinate)\u003c\/th\u003e\n\u003ctd\u003e10 mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003ctd\u003e30 sublingual strips\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eFlavour\u003c\/th\u003e\n\u003ctd\u003eMixed Berry\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch3\u003eProtocol\u003c\/h3\u003e\n\u003cp\u003eOne strip on the tongue, allow to dissolve. Maximum one strip per day.\u003c\/p\u003e\n\u003ch3\u003eSupports\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eSupports glucose metabolism within the normal range\u003c\/li\u003e\n\u003cli\u003eSupports normal enzyme activity\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eEvidence\u003c\/h3\u003e\n\u003cp class=\"rb-note\"\u003eGraded against what was actually tested. Where the trial dose differs from this strip, both numbers are shown.\u003c\/p\u003e\n\u003cdiv class=\"rb-evidence\"\u003e\n\u003cdiv class=\"rb-ev\" data-grade=\"Preliminary\"\u003e\n\u003cp class=\"rb-ev-head\"\u003e\u003cspan class=\"rb-grade\"\u003ePreliminary\u003c\/span\u003e\u003cspan class=\"rb-ev-active\"\u003eChromium\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"rb-ev-finding\"\u003eRandomised double-blind placebo-controlled crossover, 59 adults with impaired glucose tolerance or metabolic syndrome (the population most likely to respond) at 500 and 1,000 mcg for 6 months. Reported as a null result at doses far above this strip.\u003c\/p\u003e\n\u003cp class=\"rb-ev-dose\"\u003eStudied at 500–1,000 mcg\/day · This strip: 75 mcg\u003c\/p\u003e\n\u003cp class=\"rb-ev-src\"\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3118091\/\" target=\"_blank\" rel=\"nofollow noopener\"\u003eSource\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rb-ev\" data-grade=\"Preliminary\"\u003e\n\u003cp class=\"rb-ev-head\"\u003e\u003cspan class=\"rb-grade\"\u003ePreliminary\u003c\/span\u003e\u003cspan class=\"rb-ev-active\"\u003eSaffron\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"rb-ev-finding\"\u003eDouble-blind RCT, 60 mildly overweight women, 353 mg standardised saffron extract per day for 8 weeks. Significantly reduced snacking frequency (p\u0026lt;0.05). This strip carries 10 mg.\u003c\/p\u003e\n\u003cp class=\"rb-ev-dose\"\u003eStudied at 353 mg\/day · This strip: 10 mg\u003c\/p\u003e\n\u003cp class=\"rb-ev-src\"\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20579522\/\" target=\"_blank\" rel=\"nofollow noopener\"\u003eSource\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rb-ev\" data-grade=\"Preliminary\"\u003e\n\u003cp class=\"rb-ev-head\"\u003e\u003cspan class=\"rb-grade\"\u003ePreliminary\u003c\/span\u003e\u003cspan class=\"rb-ev-active\"\u003eMolybdenum\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"rb-ev-finding\"\u003eMolybdenum is an established cofactor for four human enzymes including sulfite oxidase and xanthine oxidase. Essentiality is not in question; a weight-management effect was never the claim.\u003c\/p\u003e\n\u003cp class=\"rb-ev-dose\"\u003eStudied at n\/a (review) · This strip: 10 mcg\u003c\/p\u003e\n\u003cp class=\"rb-ev-src\"\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11275037\/\" target=\"_blank\" rel=\"nofollow noopener\"\u003eSource\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch3\u003eContents\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eOther ingredients:\u003c\/strong\u003e Pullulan, Cellulose, Malic Acid, Sorbitol Syrup, Lecithin, Mixed Berry Flavor, Steviol Glycoside.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDietary:\u003c\/strong\u003e Gluten-free  ·  Vegetarian  ·  Vegan-friendly  ·  Lactose-free  ·  Hormone-free  ·  Antibiotic-free  ·  Alcohol-free  ·  Cruelty-free\u003c\/p\u003e\n\u003ch3\u003ePackaging\u003c\/h3\u003e\n\u003cp class=\"rb-note\"\u003eOnly the metal tin is branded. The individual strip packets inside ship with the manufacturer's generic label and cannot be customised.\u003c\/p\u003e\n\u003cp class=\"rb-fda\"\u003e\u003csmall\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/small\u003e\u003c\/p\u003e","brand":"RUNTIME","offers":[{"title":"30 strips","offer_id":62153861464434,"sku":"AAV9WHSU","price":35.9,"currency_code":"USD","in_stock":true}]},{"product_id":"iron","title":"RUNTIME Iron","description":"\u003cp class=\"rb-lede\"\u003eThe best-evidenced product in this catalog. Iron at 19 mg with 400 mcg folate, backed by a Cochrane review of 67 trials, plus a fatigue RCT in women who were not anaemic.\u003c\/p\u003e\n\u003cp class=\"rb-note\"\u003eIron is the one active here where the trial population, the endpoint and the dose all line up with a daily strip.\u003c\/p\u003e\n\u003ch3\u003eSpec\u003c\/h3\u003e\n\u003ctable class=\"rb-spec\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eIron (Ferric Saccharate)\u003c\/th\u003e\n\u003ctd\u003e19 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eVitamin B9 (Folate)\u003c\/th\u003e\n\u003ctd\u003e400 mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003ctd\u003e30 sublingual strips\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eFlavour\u003c\/th\u003e\n\u003ctd\u003eRaspberry\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch3\u003eProtocol\u003c\/h3\u003e\n\u003cp\u003eOne strip on the tongue, allow to dissolve. Maximum one strip per day.\u003c\/p\u003e\n\u003ch3\u003eSupports\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eSupports normal oxygen transport and red blood cell production\u003c\/li\u003e\n\u003cli\u003eSupports normal cellular function\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eEvidence\u003c\/h3\u003e\n\u003cp class=\"rb-note\"\u003eGraded against what was actually tested. Where the trial dose differs from this strip, both numbers are shown.\u003c\/p\u003e\n\u003cdiv class=\"rb-evidence\"\u003e\n\u003cdiv class=\"rb-ev\" data-grade=\"Strong\"\u003e\n\u003cp class=\"rb-ev-head\"\u003e\u003cspan class=\"rb-grade\"\u003eStrong\u003c\/span\u003e\u003cspan class=\"rb-ev-active\"\u003eIron\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"rb-ev-finding\"\u003eCochrane review of 67 RCTs covering 8,506 menstruating women. High-quality evidence that iron raised haemoglobin (mean difference +5.30 g\/L, 95% CI 4.14–6.45) and substantially reduced anaemia.\u003c\/p\u003e\n\u003cp class=\"rb-ev-dose\"\u003eStudied at daily supplementation · This strip: 19 mg\u003c\/p\u003e\n\u003cp class=\"rb-ev-src\"\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10182438\/\" target=\"_blank\" rel=\"nofollow noopener\"\u003eSource\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rb-ev\" data-grade=\"Moderate\"\u003e\n\u003cp class=\"rb-ev-head\"\u003e\u003cspan class=\"rb-grade\"\u003eModerate\u003c\/span\u003e\u003cspan class=\"rb-ev-active\"\u003eIron\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"rb-ev-finding\"\u003eRCT in 144 women aged 18–55 with unexplained fatigue but no clinical anaemia. Fatigue fell 29% on iron versus 13% on placebo (p=0.004). The trial ran at 80 mg; this strip carries 19 mg.\u003c\/p\u003e\n\u003cp class=\"rb-ev-dose\"\u003eStudied at 80 mg\/day · This strip: 19 mg\u003c\/p\u003e\n\u003cp class=\"rb-ev-src\"\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC156009\" target=\"_blank\" rel=\"nofollow noopener\"\u003eSource\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch3\u003eContents\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eOther ingredients:\u003c\/strong\u003e Pullulan, Cellulose, Lecithin, Raspberry Flavor, Monk Fruit Extract, Citric Acid, MCT, Xanthan Gum, Steviol Glycosides.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDietary:\u003c\/strong\u003e Gluten-free  ·  Vegetarian  ·  Lactose-free  ·  Allergen-free  ·  Hormone-free  ·  All-natural  ·  Antibiotic-free  ·  Alcohol-free  ·  Cruelty-free\u003c\/p\u003e\n\u003ch3\u003ePackaging\u003c\/h3\u003e\n\u003cp class=\"rb-note\"\u003eOnly the metal tin is branded. The individual strip packets inside ship with the manufacturer's generic label and cannot be customised.\u003c\/p\u003e\n\u003cp class=\"rb-fda\"\u003e\u003csmall\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/small\u003e\u003c\/p\u003e","brand":"RUNTIME","offers":[{"title":"30 strips","offer_id":62153861595506,"sku":"AAV9IRON","price":28.9,"currency_code":"USD","in_stock":true}]},{"product_id":"bone-support","title":"RUNTIME Bone","description":"\u003cp class=\"rb-lede\"\u003eD3 at 2,000 IU with K2 at 120 mcg. The K2 evidence is a 16-RCT meta-analysis; the D3-alone fracture evidence is a null result, and both are on the page.\u003c\/p\u003e\n\u003cp class=\"rb-note\"\u003eD3 without calcium did not reduce fracture risk in the pooled trials. That is stated here rather than buried.\u003c\/p\u003e\n\u003ch3\u003eSpec\u003c\/h3\u003e\n\u003ctable class=\"rb-spec\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eVitamin D3 (Cholecalciferol)\u003c\/th\u003e\n\u003ctd\u003e2,000 IU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eVitamin K2 (Menaquinone)\u003c\/th\u003e\n\u003ctd\u003e120 mcg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003ctd\u003e30 sublingual strips\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eFlavour\u003c\/th\u003e\n\u003ctd\u003eRaspberry\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch3\u003eProtocol\u003c\/h3\u003e\n\u003cp\u003eOne strip on the tongue, allow to dissolve. Maximum one strip per day.\u003c\/p\u003e\n\u003ch3\u003eSupports\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eSupports proper calcium use in the body\u003c\/li\u003e\n\u003cli\u003eSupports the maintenance of normal bone health\u003c\/li\u003e\n\u003cli\u003eSupports normal immune function\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eEvidence\u003c\/h3\u003e\n\u003cp class=\"rb-note\"\u003eGraded against what was actually tested. Where the trial dose differs from this strip, both numbers are shown.\u003c\/p\u003e\n\u003cdiv class=\"rb-evidence\"\u003e\n\u003cdiv class=\"rb-ev\" data-grade=\"Strong\"\u003e\n\u003cp class=\"rb-ev-head\"\u003e\u003cspan class=\"rb-grade\"\u003eStrong\u003c\/span\u003e\u003cspan class=\"rb-ev-active\"\u003eVitamin K2\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"rb-ev-finding\"\u003eMeta-analysis pooling 16 RCTs and 6,425 participants. K2 significantly improved bone mineral density and reduced fracture incidence in postmenopausal women, via carboxylation of osteocalcin.\u003c\/p\u003e\n\u003cp class=\"rb-ev-dose\"\u003eStudied at see source · This strip: 120 mcg\u003c\/p\u003e\n\u003cp class=\"rb-ev-src\"\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/journals\/public-health\/articles\/10.3389\/fpubh.2022.979649\/full\" target=\"_blank\" rel=\"nofollow noopener\"\u003eSource\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rb-ev\" data-grade=\"Preliminary\"\u003e\n\u003cp class=\"rb-ev-head\"\u003e\u003cspan class=\"rb-grade\"\u003ePreliminary\u003c\/span\u003e\u003cspan class=\"rb-ev-active\"\u003eVitamin D3\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"rb-ev-finding\"\u003eSystematic review and meta-analysis, 11 RCTs (34,243 participants). Vitamin D alone showed no significant reduction in fracture risk at standard doses. The benefit appeared only in combination with calcium.\u003c\/p\u003e\n\u003cp class=\"rb-ev-dose\"\u003eStudied at standard doses · This strip: 2,000 IU\u003c\/p\u003e\n\u003cp class=\"rb-ev-src\"\u003e\u003ca href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2757873\" target=\"_blank\" rel=\"nofollow noopener\"\u003eSource\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rb-ev\" data-grade=\"Moderate\"\u003e\n\u003cp class=\"rb-ev-head\"\u003e\u003cspan class=\"rb-grade\"\u003eModerate\u003c\/span\u003e\u003cspan class=\"rb-ev-active\"\u003eVitamin D3\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"rb-ev-finding\"\u003eSystematic review of 7 RCTs, 792 older adults. Resistance training combined with D3 produced a large significant improvement in lower-limb muscle strength (p\u0026lt;0.00001).\u003c\/p\u003e\n\u003cp class=\"rb-ev-dose\"\u003eStudied at see source · This strip: 2,000 IU\u003c\/p\u003e\n\u003cp class=\"rb-ev-src\"\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5541589\/\" target=\"_blank\" rel=\"nofollow noopener\"\u003eSource\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch3\u003eContents\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eOther ingredients:\u003c\/strong\u003e Pullulan, Cellulose, Lecithin, Raspberry Flavor, Malic Acid, Erythritol, Sorbitol Syrup, Pectin, Steviol Glycosides.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDietary:\u003c\/strong\u003e Gluten-free  ·  Hormone-free  ·  All-natural  ·  Antibiotic-free  ·  No fillers  ·  Corn-free\u003c\/p\u003e\n\u003ch3\u003ePackaging\u003c\/h3\u003e\n\u003cp class=\"rb-note\"\u003eOnly the metal tin is branded. The individual strip packets inside ship with the manufacturer's generic label and cannot be customised.\u003c\/p\u003e\n\u003cp class=\"rb-fda\"\u003e\u003csmall\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/small\u003e\u003c\/p\u003e","brand":"RUNTIME","offers":[{"title":"30 strips","offer_id":62153861693810,"sku":"AAV9BONE","price":28.9,"currency_code":"USD","in_stock":true}]}],"url":"https:\/\/runtimebio.com\/collections\/daily-essentials.oembed","provider":"Runtime Bio","version":"1.0","type":"link"}